Evidence for clonal origin of neoplastic neuronal and glial cells in gangliogliomas.

摘要: Gangliogliomas are rare tumors of the central nervous system that account for approximately 1% all brain tumors. Histologically, gangliogliomas composed intimately admixed glial and neuronal components, pathological origins which remain to be characterized. Clonal analysis through examination pattern X chromosome inactivation allows one distinguish monoclonal differentiation a genetically abnormal progenitor cell from parallel, but independent, clonal expansion two different types during tumorigenesis in biphasic neoplasms, such as gangliogliomas. In present study, we investigated clonality eight female patients using both methylation- transcription-based assays at androgen receptor locus (HUMARA) on chromosome. Among seven who were heterozygous HUMARA locus, five identified with methylation-based assay, results confirmed by method, whereas shown polyclonal assay analysis. We conclude predominant most origin derive common precursor subsequently differentiates form neoplastic elements.