What Is New in the Understanding of Non Healing Wounds Epidemiology, Pathophysiology, and Therapies

摘要: Chronic wounds are a growing socioeconomic problem in the western world. Knowledge on recalcitrant relies vitro studies or clinical observations, and there is emerging evidence impact of bacterial biofilm skin healing. locked inflammatory state wound healing, multiple explanations for this arrest with theory exaggerated proteolysis as most commonly accepted. Previously, has not been enough focus different etiologies chronic compared to acute, healing wounds. There an urgent need group by its cause when searching possible diagnostic therapeutic targets. Good management should therefore consist recognition basic etiology, irrigation, debridement order reduce microbial necrotic load, frequently changed dressings, appropriate antimicrobial antibiofilm strategies based precise diagnosis. Representative sampling required diagnosis treatment The present review aims at describing infections relation diagnosing, strategies, including experimentally adjuvant approaches animal models.