Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization.

摘要: Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T cells in a cell receptor (TCR) Vβ-specific manner, resulting excessive immune system activation. Staphylococcus aureus possesses repertoire distinct SAgs, and the context host-pathogen interactions, staphylococcal SAg research has focused primarily on role these severe invasive diseases. However, contribution SAgs colonization by S. remains unclear. We developed two-week nasal model using SAg-sensitive transgenic mice expressing HLA-DR4, evaluated two well-studied stains aureus. Newman produces relatively low levels enterotoxin A (SEA), although we did not detect significant TCR-Vβ specific changes during wild-type colonization, Δsea established transiently higher bacterial loads nose. COL high B (SEB), with resulted clear Vβ8-specific skewing responses. Δseb consistently These data suggest may be involved regulating densities colonization.