Exploring Time-Resolved Characterization of the Heterogeneity and Dynamics of Ligand-Receptor Interactions on Living Cells

摘要: Patients affected by malignant brain tumor present an extremely poor prognosis, notwithstanding improvements in surgery techniques and therapeutic protocols. Late diagnosis the limitation of conventional therapies are major reasons for this unsolved clinical problem. The blood-brain barrier formed a complex endothelial cells, astrocyte pericytes reduces notably diffusion large number agents. Nanotechnology involves design, synthesis, characterization materials devices that have functional organization at least one dimension on nanometer scale. nanoparticles emerged as potential vectors delivery able to overcome difficulties modern strategies. Nanoparticles drug systems can be, also, used provide targeted drugs, improve bioavailability, sustains release drugs systemic delivery. Moreover, multi-functionality be engineered into single nanoplatform so it tumor-specific detection, treatment, follow-up monitoring. In study we will focus role possibilities its overcoming. Recent studies some kinds tumors treatment summarized.