Functional characterization and developmental regulation of mouse telomerase RNA
作者： M. Blasco , W. Funk , B. Villeponteau , C. Greider
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摘要: Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human RNA. Alteration of template region in vivo generated altered products. shorter regions other rodent RNAs could account for distribution products (processivity) by enzyme relative to telomerase. Amounts increased immortal cells derived from primary fibroblasts. detected all newborn tissues tested but decreased during postnatal development.
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