Effect of Early vs Late Intervention With Inhaled Corticosteroids in Asthma

摘要: One hundred five consecutive patients with mild or moderate asthma not earlier treated inhaled corticosteroids and a need of an bronchodilator three more doses week, and/or symptoms during day night, peak expiratory flow (PEF) FEV 1 less than 75% predicted normal values were given corticosteroid for 2 years (budesonide delivered via inspiratory flow-driven multidose dry powder inhaler [Turbuhaler]). According to duration symptoms, they divided into six groups; from 6 months up 10 years. PEF measured before after treatment 3 months, year, In the groups years, mean significantly higher at all time points as compared baseline longer symptoms. The maximum effects usually seen year's maintained control second year. A significant negative correlation was found between increases in (r=-0.34;p=0.0006) (r=-0.32;p=0.0012), remaining also correcting airway function. No age regular use s -agonists improvements results give some evidence that early steroid may prevent developing chronic obstruction. They support current guidelines advocating introduction anti-inflammatory drugs.