Neuropsychological functioning and brain structure in schizophrenia

摘要: Cognitive deficits are core features of schizophrenia that already evident at early phases the illness. The study specific relationships between cognition and brain structure might provide valuable clues about neural basis its phenomenology. aim this article was to review most consistent findings studies exploring cognitive anomalies in schizophrenia. Besides several important methodological shortcomings bear mind before drawing any conclusion from revised literature, we have attempted systematically summarize these findings. Thus, has revealed whole volume tends positively correlate with a range domains healthy volunteers female patients. An association prefrontal morphological characteristics general inability control behaviour seems be present Parahippocampal is related semantic functions. Thalamic been associated executive specifically Available evidence on relationship functions cerebellar still contradictory. Nonetheless, larger cerebellum appears higher IQ controls Enlarged ventricles, including lateral third attention, premorbid functioning Several reported seem counterintuitive according drawn animal, lesion, functional imaging investigations. Therefore, there great need for more methodologically stringent investigations would help advance our understanding cognition/brain