Utilization of ferroproteins by Candida albicans during candidastasis by apotransferrin.

摘要: Many reports have stated that some of the pathogenic bacteria can obtain iron from ferroproteins, such as cytochrome C, ferritin, hemin, hemoglobin, and myoglobin. These prompted us to determine if an opportunistic fungus,Candida albicans, utilize ferroproteins circumvent iron-regulatory effect transferrin. The following assays were carried out measurein vitro growth stimulation by ferroproteins: initial step,C. albicans was cultured in iron-free (pretreated with apotransferrin for 24 h) culture medium. OnceCandida yeast cell reached stasis starvation, individual ferro-proteins added media. Results showed myoglobin supported a partial recovery. Additional studies haptoglobin, serum protein interacts globin moiety certain established thatC. could haptoglobin-ferroprotein complexes. data indicate heme part is source iron. This implies oxygenase, CaHMX1 might be involved bringing about dissociation heme-containing iron-acquisition. In addition, anticandidal activity transferrin takes place not only process regulation, but also direct interaction cells.