Variable Cell Growth Yields Reproducible Organ Development through Spatiotemporal Averaging

摘要: Organ sizes and shapes are strikingly reproducible, despite the variable growth division of individual cells within them. To reveal which mechanisms enable this precision, we designed a screen for disrupted sepal size shape uniformity in Arabidopsis identified mutations mitochondrial i-AAA protease FtsH4. Counterintuitively, through live imaging observed that variability neighboring cell was reduced ftsh4 sepals. We found regular organ results from spatiotemporal averaging cellular wild-type sepals, is less-variable cells mutants. also abnormal, increased accumulation reactive oxygen species (ROS) mutants disrupts consistency. In ROS accumulate maturing limit growth, suggesting endogenous signals promoting termination growth. Our demonstrate spatiotemporal averaging required precision size.