TAZ and YAP are frequently activated oncoproteins in sarcomas

摘要: TAZ (WWTR1) and YAP are transcriptional coactivators oncoproteins inhibited by the Hippo pathway. Herein we evaluate 159 sarcomas representing most prevalent sarcoma types immunohistochemistry for expression activation (nuclear localization) of YAP. We show that 50% demonstrate while 66% activated TAZ. Differential identified in various types. At an RNA level, WWTR1 or YAP1 predicts overall survival undifferentiated pleomorphic dedifferentiated liposarcoma. Immunohistochemistry demonstrates positively correlated with grade well-differentiated liposarcoma to tumor progression sequence as well conventional chondrosarcomas. constitutively cell lines. Knock-down differential activity two proteins. Verteporfin decreases colony formation soft agar CTGF lines harboring