Complexos de nanofibras eletrofiadas e ácidos nucleicos: Uma revisão

摘要: The interaction between cells and polymeric nanostructures has been considered an important topic for biotechnology. electrospun fibers present porous structures in the order of submicron with characteristics that mimic fibrillar components natural extracellular matrix, favoring effective local action bioactive systems. Complexation nucleic acids these their use functional recovery tissue regeneration therapies have alternatives to cell transplantation inductive protein delivery In customizing profile matrices genetic material, it is relevant maintain availability molecular types concentrations microenvironment, greater gene expression longer time therapeutic action. development adequate balance transfection efficiency viability, different strategies are followed, such as incorporation polynucleotides solutions or emulsions before electrospinning process, even functionalization nanofibers by modifying surface. Because this, this review aims methods producing electrophilic functionalized applications health area.