Role of the modulation of CYP1A1 expression and activity in chemoprevention

摘要: As one of the main extra-hepatic cytochrome P450 (CYP) enzymes, CYP1A1 has been comprehensively investigated for its ability to metabolize both exogenous and endogenous compounds into their carcinogenic derivatives. These derivatives are linked cancer initiation progression. The compound benzo-a-pyrene (BaP), a copious noxious present in coal tar, automobile exhaust fumes, cigarette smoke charbroiled food, is metabolised by studied great detail. Other reliant on same enzyme activation include 7,12 dimethylbenz(a)anthracene (DMBA) heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). This review takes an in-depth look at number phytochemicals, plant extracts few synthetic that have researched deemed potential chemopreventives via interaction with activity expression CYP1A1. It will also useful active site model Based inhibitors demonstrated vivo use as chemopreventors, initial target screening such potential, rapid vitro and/or silico assessments. Chemoprevention means which healthy tissues protected prevention, inhibition or reversal carcinogenesis. focuses important pathway carcinogenesis identifies role plays pathway. hoped highlighting importance key target, help revive further research application towards generating improved chemopreventors. Copyright © 2014 John Wiley & Sons, Ltd.