An histochemical study of the effects of immunosuppressive drug azathioprine on the cytoarchitecture of the testes of adult wistar rats (rattus norvegicus)

摘要: In this study weemployed some histochemical techniques to evaluate the effect of ascorbic acidon azathioprine-induced alterations in testis adult Wistar rats. Maleadult rats (n=30) with mean weight 210±2.65 g were assigned into fourtreatment (n=24) and control (n=6) groups. Animals treated 25 50mg/kg azathioprine (AZA) alone (Grps II IV) combination and50 mg/kg acid III V) for 21 days while animalsreceived 1 ml distilled water. 24 h Post-treatment, animals sacrificed,their testes excised, weighed fixed Bouins’ fluid histochemicalstudies reticulin collagen. The findings testissections indicated cyto-architectural distortions groups whencompared group. This show that at dosesadministered did not ameliorate damages caused by azathioprine.