Surface T cell Fas receptor/CD95 regulation, in vivo activation, and apoptosis. Activation-induced death can occur without Fas receptor

摘要: Fas-mediated apoptosis is a form of cell death that operates through receptor-ligand interaction. The FasR has been implicated directly in peripheral T tolerance and activation-induced cells vitro, although to date its expression on murine characterized incompletely. In this study, we document substantial the vast majority recent thymic emigrants resting lymphocytes. ligation can induce minor (approximately 5%) subset these cells. By contrast rather slow activation-mediated up-regulation demonstrate vivo activation by alpha CD3 mAb or superantigen results rapid FasR. This paralleled kinetics lymph node However, not necessary for death. Lymph from young, healthy, expression-deficient MRL-Ipr/Ipr animals could be activated TCR-CD3 complex. Most importantly, underwent massive response high intermediate doses CD3. At low dose, however, both MRL +/+ were similarly, but only latter adequate apoptosis. Taken together, findings suggest vivo, Fas pathway may regulator death, critical regulating responses weak stimuli.