The molecular anatomy of dynein.

摘要: Recent molecular, genetic and functional studies have led to an unparalleled growth in our understanding of dynein the roles played by various polypeptides these massive macromolecular assemblies. Dyneins are highly complex 1-2MDa complexes that function as molecular motor move cargo which they attached towards minus-end a microtubule. Dynein is property heavy chains, whereas intermediate chains involved attachment appropriate cargo. In order for useful work be obtained, cargo-binding activities must tightly controlled. Current data suggest this role certain accessory light-chain proteins. The LC8 conserved found many enzyme systems. This protein essential multicellular organisms. light Tctex1 Tctex2 been implicated non-Mendelian transmission variant forms mouse chromosome 17.