Biochemistry of apoptotic cell death.

摘要: Apoptosis is a physiological cell suicide program that critical for the development and maintenance of healthy tissues. Regulation programmed death allows organism to control number tissue size, protect itself from rogue cells threaten homeostasis. The changed activity numerous genes influences switching self-destruction program. requires co-ordinated action fine tuning set proteins are either regulators or executors process. Cancer, autoimmune diseases, immunodeficiency disease, reperfusion injury neurodegenerative disorders characterised by disregulation apoptosis. Modulation expression activation key molecular components apoptotic process has emerged as an attractive therapeutic strategy many diseases.