The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
作者： Jinhong Wie , Byung Joo Kim , Jongyun Myeong , Kotdaji Ha , Seung Joo Jeong
DOI: 10.1080/19336950.2015.1058454
关键词:
摘要: TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much known regarding the assembly function these channels including TRPC1 as a homotetramer or heteromultimer roles that their interacting proteins play controlling events. Further, they are one best-studied targets G protein-coupled receptors growth factors general Gαi/o Gαq protein coupled receptor epidermal factor leptin particular. However, our understanding small on still rudimentary. We discuss potential for Rasd1 channel activation addition to role cellular signaling.
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