Neurostimulation and reach-to-grasp function recovery following acquired brain injury: insight from pre-clinical rodent models and human applications

摘要: Reach-to-grasp is an evolutionarily conserved motor function that adversely impacted following stroke and traumatic brain injury (TBI). Non-invasive stimulation (NIBS) methods, such as transcranial magnetic direct current stimulation, are promising tools could enhance functional recovery of reach-to-grasp post-brain injury. Though the rodent literature provides a causal understanding post-injury mechanisms, it has had limited impact on NIBS protocols in human research. The high degree homology circuitry between humans rodents further implies application to be better informed by findings from pre-clinical models neurorehabilitation Here, we provide overview advantages limitations using advance our function, cortical circuitry, reorganization. We propose cross-species comparison mechanistic framework for clinically efficacious treatments elicit outcomes patients.