Constraints and plasticity in genome and molecular-phenome evolution

作者: Eugene V. Koonin , Yuri I. Wolf

DOI: 10.1038/NRG2810

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摘要: Multiple constraints variously affect different parts of the genomes diverse life forms. The selective pressures that shape evolution viral, archaeal, bacterial and eukaryotic differ markedly, even among relatively closely related animal lineages; by contrast, affecting protein seem to be more universal. phenomes are complemented plasticity robustness genome architecture, expression regulation. Taken together, these findings starting reveal complex networks evolutionary processes must integrated attain a new synthesis biology.

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