SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
作者： Yu Wang , Yan Liang , Paul M. Vanhoutte
DOI: 10.1016/J.FEBSLET.2010.11.047
关键词:
摘要: Ageing in mammals remains an unsolved mystery. Anti-ageing is a recurring topic the history of scientific research. Lifespan extension evoked by Sir2 protein lower organisms has attracted large amount interests last decade. This review summarizes recent evidence supporting role mammalian homologue, SIRT1 (Silent information regulator T1), regulating ageing and cellular senescence. The various signaling networks responsible for anti-ageing anti-senescence activity have been discussed. In particular, counter-balancing model involving cross-talks between AMP-activated kinase (AMPK), another stress energy sensor, suggested controlling senescence program cells.
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