Bronchial Colonization and Postoperative Respiratory Infections in Patients Undergoing Lung Cancer Surgery

摘要: Study objectives To evaluate the risk factors associated with postoperative respiratory infection in patients undergoing lung cancer surgery, special emphasis on perioperative pattern of airway colonization. Design Prospective cohort study. Setting Department Pneumology and Thoracic Surgery a tertiary hospital. Patients Seventy-eight consecutive surgery were evaluated. followed up until hospital discharge or death. Interventions Fiberoptic bronchoscopies bilateral protected specimen brush bronchial aspirates performed during anesthesia prior to initiation surgical procedure. Results Sixty-five (83%) had colonization by either potentially pathogenic microorganisms (PPMs) [28 patients, 36%] nonpotentially (56 72%). The 24 (31%) (pneumonia, purulent tracheobronchitis, pleural empyema) significantly higher PPMs (15 [63%] vs 13 [24%], p=0.003) bacterial index (mean ± SD, 3.6 3.3 0.9 1.4; p=0.003), compared without infection. agreement between pathogens found evaluation was total 5 (21%), partial no concordance 14 (58%). In multivariate analysis, presence PPM (odds ratio [OR], 6.9; p=0.001) pain score (OR, 4.1; p=0.014) independent predictors Conclusion Adequate control pain, as well conditions that cause PPMs, could be beneficial preventing infections after surgery.