Expired nitric oxide after bronchoprovocation and repeated spirometry in patients with asthma.
作者： AARON DEYKIN , ORIT HALPERN , ANTHONY F. MASSARO , JEFFREY M. DRAZEN , ELLIOT ISRAEL
DOI: 10.1164/AJRCCM.157.3.9707114
关键词:
摘要: Compared with normal individuals, subjects asthma have elevated levels of expired nitric oxide (NO). These are hypothesized to reflect the degree airway inflammation. Expired NO rise during late phase allergen challenge and decrease in asthmatics after steroid treatment. Isocapnic cold air hyperventilation (ISH) is believed cause narrowing through noninflammatory mechanisms. We measured mixed 10 individuals atopic who underwent both ISH challenge, compared these measurements change that occurred serial spirometry alone. found ambient affected NO. Controlling for inspired NO, we repeated alone produced a significant fall (p < 0.01) was maximal 30 min (36.6 ± 8.5% fall). After challenges, relative 0.01 p = 0.065, respect...
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