Mechanical load affects growth and maturation of skeletal muscle grafts

摘要: The purpose of our study was to determine whether the early patterns growth and maturation regenerating soleus muscle grafts are sensitive alterations in mechanical load. We hypothesized that decreased increased loading would reduce accelerate, respectively, rate magnitude impair enhance, pattern maturation. On day 0, muscles were grafted rats assigned one three groups: cage sedentary (normal load), hindlimb suspension (decreased or ablation synergist (increased load). From days 7 35, graft mass cage-sedentary at a 1.85 mg mass/day. Rates less for suspended greater ablated (-1.06 3.89 mass/day, respectively; P < 0.01). Neonatal myosin heavy chain (MHC) reached 10 +/- 1.6% total MHC rats, whereas animals it 11 2.4% 14. At 21 from had lower proportion slow (45 2.4%) than did control groups (95 1.5%; 0.05). Decreased load impaired degree during regeneration, enhanced characteristics but not