Cytogenetic studies of Hodgkin's disease. Analysis of involved lymph nodes from 12 patients.
作者： Thomas R. Dennis , A.Dean Stock , Carl D. Winberg , Khalil Sheibani , Henry Rappaport
DOI: 10.1016/0165-4608(89)90049-6
关键词:
摘要: Cytogenetic studies were performed on 12 involved lymph nodes from Hodgkin's disease patients utilizing conditioned medium 12-O-tetradecanoylphorbol-13-acetate-staphylococcus enterotoxin A induced mononuclear cells. The majority of cells analyzed had a normal karyotype. An unusually high rate nonclonal karyotypic abnormalities was noted in most cultures. Clonal involving chromosomes 3 and 21 two patients. analysis cultures stimulated with or specific growth factors may lead to better understanding the genetic mechanisms disease.
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