Hyaluronic acid-coated polymeric micelles with hydrogen peroxide scavenging to encapsulate statins for alleviating atherosclerosis.
作者： Dan Mu , Jianhui Li , Yu Qi , Xuan Sun , Yihai Liu
DOI: 10.1186/S12951-020-00744-W
关键词:
摘要: Inflammation and oxidative stress are two major factors that involved in the pathogenesis of atherosclerosis. A smart drug delivery system responds to microenvironment atherosclerotic plaques was constructed present study. Simvastatin (SIM)-loaded biodegradable polymeric micelles were from hyaluronic acid (HA)-coated poly(ethylene glycol)-poly(tyrosine-ethyl oxalyl) (PEG-Ptyr-EO) for purpose simultaneously inhibiting macrophages decreasing level reactive oxygen species (ROS) treat HA coating endows micelle ability targeting CD44-positive inflammatory macrophages. Owing ROS-responsive nature PEG-Ptyr-EO, can not only be degraded by enzymes, but also consumes ROS itself at pathologic sites, upon which accumulation pro-inflammatory is effectively suppressed alleviated. Consequently, cellular uptake experiment demonstrated SIM-loaded HA-coated internalized LPS-induced RAW264.7 cells showed high cytotoxicity against cells, low LO2 cells. In mouse models atherosclerosis, intravenously reduce plaque content cholesterol, resulting remarkable therapeutic effects. conclusion, provides a promising innovative option
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