作者: Natalie Galanina , Veerle Bossuyt , Lyndsay N. Harris
DOI: 10.1097/PPO.0B013E318212DEE3
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摘要: For several decades, measurements from tumor tissue biomarkers have been used to identify subsets of breast cancer patients that may benefit specific therapies. Since the 1980s, estrogen receptor testing has routinely performed on carcinoma samples determine whether hormonal therapy is indicated. Today, receptor, progesterone and human epidermal growth factor type 2 guide treatment decisions are standard care. In recent years, multigene assays introduced predict behavior. particular, OncotypeDx MammaPrint commercialized in North America Europe clinical decisions. Others, including Breast Cancer Index (BCI; bioTheranostics) PAM50 (Expression Analysis, Inc), gaining acceptance as validated with associated outcomes. addition, certain germ line genetic tests now reported response treatments (e.g., BRCA1, 2, CYP2D6). The optimal use these novel molecular a challenge practicing oncologist. this review, we will focus role provide framework for oncologists understand evaluate tools practice.