Binding of indapamide to serum proteins and erythrocytes
作者： S. Urien , P. Riant , A. Renouard , B. Coulomb , I. Rocher
DOI: 10.1016/0006-2952(88)90282-1
关键词:
摘要: Abstract The binding of indapamide to isolated serum proteins and erythrocytes was studied in order understand its blood distribution. In serum, mainly bound α1-acid glycoprotein with a high affinity (K = 73.4/mM), albumin lipoproteins. Indapamide via saturable process 385/mM N 57 μM for an hematocrit value 0.48), were the main component (more than 80% associated blood). affected distribution blood, shown be more effective protein decreasing amount erythrocytes.
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