Architecture based selectivity of Amphiphilic block copolymers of poly(ethylene oxide) and poly(ε-caprolactone) for drug delivery
作者： Imdad Ali , Faheem Kareem , Sana Rahim , Samina Perveen , Shakil Ahmed
DOI: 10.1016/J.REACTFUNCTPOLYM.2020.104553
关键词:
摘要: Abstract Architecture of amphiphilic block copolymers is an important parameter that affects their critical micelles concentration (CMC), drug loading capacity and release behavior. In this context, 4-arm star-shaped comprising poly(ethylene oxide) as a hydrophilic segment poly(e-caprolactone) hydrophobic part, 4 s-P(CL-b-EO), compared with its linear counterpart having otherwise similar total molar mass, chemical composition mass individual components (PCL-b-PEO-b-PCL). As first step, the prepared by copolymer (LPM) (SPM) were for CMC, encapsulation capacity, Micelles based on polymers found to have low high better sustained Blood hemolysis cytotoxicity studies both revealed these are safer use biological applications. star shaped further employed delivery cefixime (CEF) co-delivery clarithromycin (CLA). Finally, growth inhibition efficiency SPM, LPM, CEF, CLA, CEF-SPM, CEF-LPM, CEF-CLA-SPM, CEF-CLA-LPM evaluated against S. pneumoniae (resistant) antibacterial assay morphological topography imaging AFM. Minimum inhibitory (MIC50) drugs encapsulated in SPM be considerably lower direct application LPM.
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