Recent approaches to the treatment of urinary incontinence: a survey of patent activity from 1995 to 1998

作者: John A Butera , Thomas M Argentieri

DOI: 10.1517/13543776.8.8.1017

关键词:

摘要: In its broadest sense, urinary incontinence (UI) is defined as involuntary loss of urine to such an extent become a hygienic or social concern the patient [1]. Up 50% patients suffering from this disorder do not seek medical attention due embarrassment their willingness accept condition ‘normal’ course ageing. Thus, often goes undiagnosed and untreated, and, in serious cases, may exact staggering toll on self-esteem psychological outlook those it affects. UI usually classified into four types: stress, urge, overflow functional. The first three types refer dysfunctions either storage emptying, while latter occurs with relatively normal lower tract, but who, nevertheless, suffer severe cognitive impairment immobility that precludes voiding behaviour. Much currently available pharmacological intervention includes use antimuscarinics/spasmolytics for...

参考文章(57)
Chen-Yu Cheng, Hsin-I Chiu, Ming-Jyh Chang, Yen-Chung Lin, Ming-Cheng Tsai, Hon-Cheng Yu, Synthesis of 2,3,4a,11b-tetrahydro-oxazino[2,3-c]benzopyran-9-carbonitriles as ATP-sensitive potassium channel openers Bioorganic & Medicinal Chemistry Letters. ,vol. 8, pp. 463- 468 ,(1998) , 10.1016/S0960-894X(98)00046-8
Kim Lawson, Potassium channel activation: A potential therapeutic approach? Pharmacology & Therapeutics. ,vol. 70, pp. 39- 63 ,(1996) , 10.1016/0163-7258(96)00003-4
George S. Benson, Stuart A. Sarshik, David M. Raezer, Alan J. Wein, Bladder muscle contractility comparative effectsand mechanisms of action of atropine, propantheline, flavoxate, and imipramine Urology. ,vol. 9, pp. 31- 35 ,(1977) , 10.1016/0090-4295(77)90279-5
Yoshinobu Yamazaki, Hiroo Takeda, Masuo Akahane, Yasuhiko Igawa, Osamu Nishizawa, Yukiyoshi Ajisawa, Species differences in the distribution of β-adrenoceptor subtypes in bladder smooth muscle British Journal of Pharmacology. ,vol. 124, pp. 593- 599 ,(1998) , 10.1038/SJ.BJP.0701870
Steen Walter, Hans Wolf, Henrik Barlebo, Haakon Kaalund Jensen, Urinary Incontinence in Postmenopausal Women Treated with Estrogens Urologia Internationalis. ,vol. 33, pp. 135- 143 ,(1978) , 10.1159/000280190
Karl-Erik Andersson, The overactive bladder: Pharmacologic basis of drug treatment Urology. ,vol. 50, pp. 74- 84 ,(1997) , 10.1016/S0090-4295(97)00595-5
I. Ehr�n, J. Adolfsson, N. P. Wiklund, Nitric oxide synthase activity in the human urogenital tract Urological Research. ,vol. 22, pp. 287- 290 ,(1994) , 10.1007/BF00297196
M. Tonini, E. Messori, G.P. Franceschetti, C.A. Rizzi, A.F. Castoldi, T. Coccini, S.M. Candura, Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle. British Journal of Pharmacology. ,vol. 113, pp. 1- 2 ,(1994) , 10.1111/J.1476-5381.1994.TB16163.X
S. Walter, B. Kj�rgaard, G. Lose, J. T. Andersen, L. Heisterberg, H. Jakobsen, P. Klarskov, K. M�ller-Hansen, M. Lindskog, Stress urinary incontinence in postmenopausal women treated with oral estrogen (estriol) and an alpha-adrenoceptor-stimulating agent (phenylpropanolamine): A randomized double-blind placebo-controlled study International Urogynecology Journal. ,vol. 1, pp. 74- 79 ,(1990) , 10.1007/BF00600025