Tamoxifen blocks both proliferation and voltage-dependent K+ channels of neuroblastoma cells.
作者： Béatrice Rouzaire-Dubois , Jean-Marc Dubois
DOI: 10.1016/0898-6568(90)90069-M
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摘要: Abstract The effects of tamoxifin (TAM) on cell proliferation and voltage-dependent K + channels were studied the mouse neuroblastoma cells NG 108-15. TAM inhibited with an effective dose inducing a half maximum effect (ED 50 ) 2 μM was cytotoxic for beyond 2.5 μM. accelerated apparent inactivation whole current dissociation constant 0.46 μM, shifted peak conductance-voltage curve towards negative voltages 1.07 flux at resting potential, calculated from time integral recorded during depolarizations, decreased by TAM. perfectly correlated restling flux. results suggest that mitosis is, in some way, controlleld functioning antitumour action tamoxifen could be due to its interaction channels.
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