A Photoinduced Cyclization Cascade—Total Synthesis of (−)‐Leuconoxine

作者: Magnus Pfaffenbach , Tanja Gaich

DOI: 10.1002/CHEM.201500656

关键词:

摘要: A protecting-group-free and enantioselective total synthesis of the monoterpenoid indole alkaloid (−)-leuconoxine was accomplished. The key step comprises a novel photoinduced domino macrocyclization/transannular cyclization involving Witkop cyclization, for which additional mechanistic evidence is provided. This process furnishes diaza[5.5.6.6]fenestrane skeleton, hitherto unprecedented structure element.

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