作者: Magnus Pfaffenbach , Tanja Gaich
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摘要: A protecting-group-free and enantioselective total synthesis of the monoterpenoid indole alkaloid (−)-leuconoxine was accomplished. The key step comprises a novel photoinduced domino macrocyclization/transannular cyclization involving Witkop cyclization, for which additional mechanistic evidence is provided. This process furnishes diaza[5.5.6.6]fenestrane skeleton, hitherto unprecedented structure element.