Effect of Meloxicam on Lipoxygenase Activity in Trachea, Skin, Stomach and Serum of Rabbits (in Vivo and in Vitro)
作者： Nadia Z. Shaban , Ahmed A. Abdul-Aziz
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摘要: The effect of meloxicam (MLX: 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3- carboxamide-1,1-dioxide.) on lipoxygenase enzyme (LOX) in different tissues rabbits vitro and vivo were studied. MLX (117 nM) inhibited trachea, skin, stomach serum LOX activities with varying inhibitory degrees. administration (0.214 mg/kg body mass/day for 7days) skin activities. However, had no activity. Linweaver-Burk plots showed that by competitive inhibition manner. values Km Vmax the absence presence determined. (Nadia Z. Shabanand Ahmed A. Abdul-Aziz. Effect Meloxicam Lipoxygenase Activity Trachea, Skin, Stomach Serum Rabbits (in Vivo Vitro). Life Sci J 2014;11(6):48-55). (ISSN:1097-8135). http://www.lifesciencesite.com . 7
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