The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level

摘要: Transcriptomic reprogramming is critical to the coordination between growth and cell cycle progression in response changing extracellular conditions. In Saccharomyces cerevisiae, transcription factor Gcr1 contributes this by supporting maximum expression of G1 cyclins addition regulating both glucose-induced glucose-repressed genes. We report here comprehensive genome-wide profiling gcr1Δ cells. Our data show that reduced ribosomal protein genes cells detectable 20 min after glucose steady-state cultures raffinose-grown cells, showing defect not result slow or on a repressing sugar. However, large phenotype mutant occurs only presence sugars. GCR1 deletion also results aberrant derepression numerous repressed loci; glucose-grown actively respire, demonstrating global alteration corresponds significant changes at physiological level. These offer an insight into division providing integrated view transcriptomic, phenotypic, metabolic consequences deletion.