Self-Assembled Colloidal Gel Using Cell Membrane-Coated Nanosponges as Building Blocks

摘要: Colloidal gels consisting of oppositely charged nanoparticles are increasingly utilized for drug delivery and tissue engineering. Meanwhile, cell membrane-coated becoming a compelling biomimetic system innovative therapeutics. Here, we demonstrate the successful use as building blocks to formulate colloidal gel that gelates entirely based on material self-assembly without chemical cross-linking. Specifically, prepare red blood nanosponges mix them with an appropriate amount cationic nanoparticles, resulting in spontaneously formed gel-like complex. Rheological test shows nanosponge has pronounced shear-thinning property, which makes it injectable formulation. The formulation not only preserves nanosponges’ toxin neutralization capability but also greatly prolongs their retention time after subcutaneous injection into mouse tissue. When tested model gro...