Modulation of immune responses by the neuropeptide CGRP

摘要: The peripheral nervous system is connected with lymphoid organs through sensory nerves that mediate pain reflexes and may influence immune responses the release of neuropeptides such as calcitonin gene-related peptide (CGRP). Local systemic levels CGRP increase rapidly during inflammatory responses. inhibits effector functions various cells dampens inflammation by distinct pathways involving amplification IL-10 production and/or induction transcriptional repressor inducible cAMP early (ICER). Thus, available evidence suggests that, in neuro-immunological interactions, mediates a potent peptidergic anti-inflammatory pathway.