Clinicopathologic correlation of hypocomplementemic and normocomplementemic urticarial vasculitis.

摘要: Background Urticarial vasculitis is characterized by persistent urticarial lesions with histologic evidence of leukocytoclastic vasculitis. Hypocomplementemic (HUV) a distinct clinical entity in subset patients Objective We examined presentation and factors predictive connective tissue disease. Methods The clinical, histologic, immunologic characteristics 132 seen at the Mayo Clinic were examined, features hypocomplementemic compared those normocomplementemic patients. Results Twenty-four (18%) had hypocomplementemia; all female. Interstitial dermal neutrophilia was 19 biopsy specimens (83%). On direct immunofluorescence (DIF) testing lesional skin, 23 (96%) continuous strong granular deposition immunoreactants along basement membrane zone compatible lupus erythematosus addition to vascular fluorescence. Systemic (SLE) present or occurred 13 (54%). One hundred eight (82%) normocomplementemia; 65 (60%) 11 26 (42%) randomly selected specimens. DIF, one patient (1%) band. SLE three (3%). Conclusion Patients HUV more likely be female, have diffuse on stained hematoxylin eosin, than submit that represents shared laboratory, features.