Neuropsin regulates an early phase of schaffer-collateral long-term potentiation in the murine hippocampus.
作者： Shoji Komai , Tomohiro Matsuyama , Kazumasa Matsumoto , Keiko Kato , Masayuki Kobayashi
DOI: 10.1046/J.1460-9568.2000.00035.X
关键词:
摘要: We found that neuropsin, an extracellular matrix serine protease, has a regulatory effect on Schaffer-collateral long-term potentiation (LTP) in the mouse hippocampus. Bath application of 1-170 nM recombinant neuropsin modulated early phase LTP pathway with 'bell-shape' dose-response curve. The maximum enhancing activity (134% control LTP) was at approximately 2.5 nM. neutralizing antibody against hippocampal slice resulted marked inhibition tetanus-induced LTP. vivo continuous intraventricular infusion antisense oligonucleotide significantly reduced amplitude vitro. Neuropsin did not directly change N-methyl D-aspartate (NMDA) current. Thus, appears to act as molecule via its proteolytic function rather than affecting NMDA receptor-mediated calcium increase.
sci-hub.se 参考文章(39)
Christian M. Müller, Claudius B. Griesinger, Tissue plasminogen activator mediates reverse occlusion plasticity in visual cortex. Nature Neuroscience. ,vol. 1, pp. 47- 53 ,(1998) , 10.1038/248
ZL Chen, S Yoshida, K Kato, Y Momota, J Suzuki, T Tanaka, J Ito, H Nishino, S Aimoto, H Kiyama, Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus The Journal of Neuroscience. ,vol. 15, pp. 5088- 5097 ,(1995) , 10.1523/JNEUROSCI.15-07-05088.1995
Ursula Stäubli, Daniel Chun, Gary Lynch, TIME-DEPENDENT REVERSAL OF LONG-TERM POTENTIATION BY AN INTEGRIN ANTAGONIST The Journal of Neuroscience. ,vol. 18, pp. 3460- 3469 ,(1998) , 10.1523/JNEUROSCI.18-09-03460.1998
Michael S. Grotewiel, Christine D. O. Beck, Kwok Hang Wu, Xin-Ran Zhu, Ronald L. Davis, Integrin-mediated short-term memory in Drosophila Nature. ,vol. 391, pp. 455- 460 ,(1998) , 10.1038/35079
Ben A. Bahr, Ursula Staubli, Peng Xiao, Daniel Chun, Zhan-Xin Ji, Everard T. Esteban, Gary Lynch, Arg-Gly-Asp-Ser-Selective Adhesion and the Stabilization of Long-Term Potentiation: Pharmacological Studies and the Characterization of a Candidate Matrix Receptor The Journal of Neuroscience. ,vol. 17, pp. 1320- 1329 ,(1997) , 10.1523/JNEUROSCI.17-04-01320.1997
M Maletic-Savatic, R Malinow, K Svoboda, Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity Science. ,vol. 283, pp. 1923- 1927 ,(1999) , 10.1126/SCIENCE.283.5409.1923
L. Whitesell, D. Geselowitz, C. Chavany, B. Fahmy, S. Walbridge, J. R. Alger, L. M. Neckers, Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 4665- 4669 ,(1993) , 10.1073/PNAS.90.10.4665
John Larson, Darryl Wong, Gary Lynch, Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation. Brain Research. ,vol. 368, pp. 347- 350 ,(1986) , 10.1016/0006-8993(86)90579-2
Fen-Lei F. Chang, William T. Greenough, Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice. Brain Research. ,vol. 309, pp. 35- 46 ,(1984) , 10.1016/0006-8993(84)91008-4
Lixin Tang, Chou P Hung, Erin M Schuman, A ROLE FOR THE CADHERIN FAMILY OF CELL ADHESION MOLECULES IN HIPPOCAMPAL LONG-TERM POTENTIATION Neuron. ,vol. 20, pp. 1165- 1175 ,(1998) , 10.1016/S0896-6273(00)80497-3