Clinical trials of Shigella vaccines in Israel.

摘要: Shigellosis or bacillary dysentery is caused by organisms belonging to genus Shigella, divided into four species (S. dysenteriae, S. boydii, S.flexneri and sonnei). With the exception of sonnei which has a single serotype, each several serotypes according O-polysaccharide antigen cell wall dysenteriae 12 serotypes, flexneri 6 boydii 18 serotypes). Shigella spp. are invasive that penetrate enterocytes colon epithelium, escape very quickly from phagocytic vacuole multiplicate intracellularly. Although non-motile, shigellae can move on an actin skeleton spread adjacent cells. The inflammatory process usually limited lamina propria does not involve deeper, submucosa. Pathogenesis in associated with constellation genes encoded both chromosome large 140 MDa virulence plasmid. These be two groups: regulatory structural genes. plasmid encodes for all essential invasion epithelium colon. Regulatory located chromosome.