COCAINE-INDUCED IMPULSIVITY IS DIFFERENTIALLY EXPRESSED IN MALE AND FEMALE MICE EXPOSED TO MATERNAL SEPARATION AND IS ASSOCIATED WITH ALTERATIONS IN AMPA RECEPTORS SUBUNITS.

摘要: Impulsivity is a key trait in the diagnosis of major depressive disorder (MDD) and substance use (SUD). MDD chronic illness characterized by sadness, insomnia, loss interest. SUD relapsing consumption drugs despite their negative consequences. Among abuse, cocaine most consumed psychostimulant. Animal studies demonstrated that increased impulsivity predicts predisposition to acquire self-administration (SA) behaviour with an cocaine-intake. Moreover, early-life stress represents vulnerability factor develop disorders drug addiction. Maternal separation early weaning (MSEW) animal model allows examining impact on abuse. In this study, we aimed explore changes MSEW-induced determine potential associations between depression-like cocaine-seeking behaviours male female mice. We also evaluated possible alterations AMPA receptors (AMPArs) composition glutamatergic neurotransmission. exposed mice MSEW behavioural tests were performed during adulthood. GluA1, GluA2 mRNA protein expression medial Prefrontal Cortex (mPFC). Results showed higher impulsive females, independently MSEW, as well increase GluA1 expression. induced downregulation Gria2 GluA1/GluA2 ratio, only conclusion, expressed mPFC function, which potentiated SA. Also, data indicated alters function mice, increasing excitability.