Hydroxyethyl Starch and Reperfusion Injury

摘要: “Blood...appears to carry life every part of the body, for whenever, whole or a parts is deprived fresh blood it very soon dies”[1]. This statement, made in early 19th century seems intuitively obvious;and indeed has served as foundation clinical management ischemia – restore perfusion. However, last decade become apparent that re-establishment flow ischemic tissue not only restores energy supply and removes toxic metabolites but, paradoxically, may worsen originals injury [2]. Free radical formation, release inflammatory mediators, capillary leakiness result [3–6]. Most attempts microvascular function have been directed at prevention correction bichemical aberrations occur during on reperfusion. Clinical examples potentials reperfusion are demonstrated Table 1.