Ketamine prevents ischemic neuronal injury.

摘要: The dissociative anesthetic ketamine hydrochloride antagonizes the excitotoxic action of excitatory amino acids in central nervous system. Proposals that acid neurotransmitters may become and contribute to pathophysiology ischemic brain injury prompted us examine a model global cerebral ischemia gerbils. Pretreatment with doses ameliorated dose-dependent manner both behavioral histopathological assessments neuronal injury. These neuroprotective effects are proposed result from specific antiexcitotoxic rather than general anticonvulsant drug action. There be clinical situations which actions would therapeutic importance.