Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens

摘要: Biological disease models can be difficult and costly to develop use on a routine basis. Particularly, in vivo lung infection performed study pathologies laborious, demand great time commonly are associated with ethical issues. When infections experimental animals used, they need refined, defined, validated for their intended purpose. Therefore, alternative easy handle of still needed test the virulence bacterial pathogens. Because non-mammalian have less cost constraints as subjects experimentation, some cases would appropriated include these valuate tools explore host-pathogen interactions. Numerous scientific data been argued more extensive several kinds models, such as, vertebrate zebrafish (Danio rerio), non-vertebrate insects nematodes (e.g. Caenorhabditis elegans) diverse infectious agents that affect humans. Here we review agents, which considered principal causes injury. Curiously none respiratory system air-breathing vertebrates, where respiration takes place lungs. Despite this fact, present sought provide elements favour animal reveal molecular signatures