Ultrahigh surface sensitivity of deposited gold nanorod arrays for nanoplasmonic biosensing

摘要: Abstract The biosensing performance of plasmonic nanostructures critically depends on detecting changes in the local refractive index near sensor surface, which is referred to as surface sensitivity. For applications at solid-liquid interfaces, recent efforts boost sensitivity have narrowly focused laterally isotropic nanostructures, while there an outstanding need explore anisotropic such nanorods that distinct properties. Herein, we report development gold nanorod (AuNR) arrays exhibit ultrahigh detect various classes biomacromolecular interactions with superior performance. A colloidal deposition strategy was devised fabricate AuNR-coated glass substrates, along experimental measurements and analytical calculations investigate how dimensions dielectric environment affect To validate sensing concept, real-time experiments involving protein adsorption peptide-induced vesicle rupture were conducted revealed rationally tuning could yield AuNR highest reported degree compared a wide range tested past studies. We discuss factors contribute this measurement capabilities developed study are broadly extendable applications.