Colonization with Heligmosomoides polygyrus Suppresses Mucosal IL-17 Production

摘要: Helminth exposure appears to protect hosts from inappropriate inflammatory responses, such as those causing bowel disease. A recently identified, strongly proinflammatory limb of the immune response is characterized by T cell IL-17 production. Many autoimmune type diseases are associated with release. Because helminths these diseases, we examined production in helminth-colonized mice. We colonized mice Heligmosomoides polygyrus, an intestinal helminth, and analyzed lamina propria mononuclear cells (LPMC) mesenteric lymph node (MLN) cells. Colonization H. polygyrus reduces IL-17A mRNA MLN inhibits cultured LPMC augments IL-4 IL-10 Blocking both IL-10, but not alone, restores vitro. colitic IL-10-deficient suppresses improves colitis. Ab-mediated blockade colitis Thus, helminth-associated inhibition most likely important mechanism mediating protection inflammation.