Genetic variants in MAPK10 modify renal cell carcinoma susceptibility and clinical outcomes.

摘要: Abstract Aims The mitogen-activated protein kinase (MAPK) cascades integrate various upstream signals to regulate many cellular functions, including proliferation, differentiation, and survival. Dysregulation of these pathways has been implicated in the occurrence progression a variety cancers. Main methods This study aimed assess association 192 single nucleotide polymorphisms 22 MAPK cascade genes with renal cell carcinoma (RCC) risk survival 312 patients 318 controls. Key findings After multiple testing correction multivariate analysis, minor T allele MAPK10 rs12648265 remained associated lower RCC (adjusted odds ratio 0.64, 95% confidence interval 0.50–0.82, P = 0.000426) metastasis hazard 0.50, 0.30–0.82, P = 0.006). Presence demonstrated trend towards being increased expression, meta-analysis four datasets indicated that high expression is favourable prognosis. Furthermore, activation by potent agonist anisomycin inhibited growth vitro, suggesting an involvement progression. Significance In conclusion, may be meaningful biomarker potential therapeutic target RCC.