Cell kinetics of mucosal atrophy in rat stomach induced by long-term administration of ammonia
作者： Masahiko Tsujii , Sunao Kawano , Shingo Tsuji , Toshifumi Ito , Kouichi Nagano
DOI: 10.1016/0016-5085(93)91015-A
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摘要: Abstract Background: Helicobacter pylori produces ammonia in the stomach from urea. The present study was undertaken to clarify whether has an etiological role H. pylori-associated gastric mucosal atrophy. Methods: Ammonia at 0.01% administered as drinking water for 8 weeks and cell migration rate proliferation were investigated rat stomach. Results: Long-term administration of 4–8 decreased thickness antrum but not body. Acceleration preceded occurrence Labeling indices both antral body mucosa significantly increased all ammonia-treated groups, compared with those control group. In antrum, proliferative zone enlarged atrophy developed, whereas, mucosa, enlargement occurred despite absence Conclusion: accelerates epithelial migration, especially leading occurs during development
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sci-hub.se 参考文章(27)
W.E. Karnes, I.M. Samloff, M. Siurala, M. Kekki, P. Sipponen, S.W.R. Kim, J.H. Walsh, Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis Gastroenterology. ,vol. 101, pp. 167- 174 ,(1991) , 10.1016/0016-5085(91)90474-Y
Toshifumi Ito, Norio Hayashi, Yutaka Sasaki, Yasuhiro Morita, Sunao Kawano, Hideyuki Fusamoto, Nobuhiro Sato, Masaya Tohyama, Takenobu Kamada, Sequential protooncogene expression during regeneration in rat stomach Gastroenterology. ,vol. 98, pp. 1525- 1531 ,(1990) , 10.1016/0016-5085(90)91085-K
George B. Jerzy Glass, C.S. Pitchumoni, Atrophic gastritis Human Pathology. ,vol. 6, pp. 219- 250 ,(1975) , 10.1016/S0046-8177(75)80177-8
Ramzi T. Assad, Gregory L. Eastwood, Epithelial proliferation in human fundic mucosa after antrectomy and vagotomy Gastroenterology. ,vol. 79, pp. 807- 811 ,(1980) , 10.1016/0016-5085(80)90433-3
Malcolm C. Townsley, Anthony M. Paradiso, Terry E. Machen, Na/H exchange in antral cells isolated from Necturus, rabbit, and guinea pig Gastroenterology. ,vol. 95, pp. 302- 310 ,(1988) , 10.1016/0016-5085(88)90484-2
W. B. Busa, R. Nuccitelli, Metabolic regulation via intracellular pH. American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 246, ,(1984) , 10.1152/AJPREGU.1984.246.4.R409
Patterns of Nucleic Acid and Protein Synthesis in Normal Human Gastric Mucosa and Atrophic Gastritis Journal of the National Cancer Institute. ,vol. 48, pp. 1567- 1574 ,(1972) , 10.1093/JNCI/48.6.1567
Michael F. Dixon, Judith I. Wyatt, Denis A. Burke, Barrie J. Rathbone, Lymphocytic gastritis—relationship toCampylobacter pylori infection The Journal of Pathology. ,vol. 154, pp. 125- 132 ,(1988) , 10.1002/PATH.1711540204
T. Hattori, B. Helpap, P. Gedigk, The morphology and cell kinetics of pseudopyloric glands Virchows Archiv B Cell Pathology Including Molecular Pathology. ,vol. 39, pp. 31- 40 ,(1982) , 10.1007/BF02892834
Leonard R. Johnson, Physiology of the Gastrointestinal Tract ,(1994)