Cancer to bone: a fatal attraction
作者： Katherine N. Weilbaecher , Theresa A. Guise , Laurie K. McCauley
DOI: 10.1038/NRC3055
关键词:
摘要: When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize sculpt microenvironment enhance growth promote invasion. Understanding crucial components that influence localization, along with tumour-derived factors modulate cellular protein matrix favour expansion invasion, is central pathophysiology metastases. Basic findings tumour–bone interactions have uncovered numerous therapeutic opportunities focus on prevent treat
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