Ontogeny and perinatal modulation of gene expression in rat brown adipose tissue : unaltered iodothyronine 5'-deiodinase activity is necessary for the response to environmental temperature at birth

摘要: We have performed a sequential study on the abundance of mRNA for uncoupling protein (UCP), subunit II cytochrome-c oxidase (COII) and lipoprotein lipase in brown adipose tissue during fetal postnatal periods. Moreover, we determined whether these parameters can be modulated by ambient temperature early hours after birth, at which point development this sensitivity first appears. UCP gene expression neonatal period has particular features when compared with overall mitochondriogenesis (COII expression) or mRNA. There is specific induction UCP between days 18 19 pregnancy followed increase utero further birth. The acquisition physiological apparatus capable response to environmental not achieved until last day development. This result suggests that mechanisms β-adrenergic modulation fat are already established birth. From an experiment iopanoic acid treatment pregnant mothers, it was concluded iodothyronine 5′-deiodinase activity necessary mRNAs UCP, COII fetus whereas