Current assays for HIV-1 diagnostics and antiretroviral therapy monitoring: challenges and possibilities

摘要: In 2011, there were over 34 million people living with HIV infections, placing a heavy burden on public health sectors. infection is lifelong threat that cannot be prevented by vaccination or cured antiretroviral drugs. The infected patients rely daily therapy to suppress viral replication. Hence, it important diagnose infections as early possible and monitor the efficacy of every 3–6 months. Different immunoassays detecting antigens antibodies have been modified offer better sensitivity more rapid diagnosis. Several clinical virological parameters, including CD4+ cell counts, load drug resistance mutations, are also used for treatment monitoring. Many molecular assay optimizations now being utilized improve patient care. This review will focus most updated diagnostic assays, well discussing upcoming possibilities other advanced technologies.