A large outbreak of Q fever in the West Midlands: windborne spread into a metropolitan area?

摘要: The largest outbreak of the zoonotic disease Q fever recorded in United Kingdom (UK) occurred Birmingham 1989. One hundred and forty-seven cases were identified, 125 whom males, 130 between 16 64 years age. Fewer Asian ethnic origin observed than expected (p < 0.01), more smokers 0.005). A case control study (26 52 matched controls) produced no evidence that direct contact with animals or animal products had caused outbreak. epidemic curve suggested a point source exposure week beginning 10 April. home addresses clustered rectangle 11 miles (18.3 km) north/south by 4 (6.7 east/ west, attack rates became lower towards north. Directly south this area farms engaged outdoor lambing calving, potent coxiella spores. retrospective computerised analysis showed geographical distribution was associated 0.00001). On April, unusual southerly gales up to 78 mph (130 km/h) recorded. probable cause windborne spread spores from farmland conurbation.